For the fifth year in a row, Jennifer Aniston is standing up in support of St. Jude's Children's Hospital; but this year, that support includes a new PSA and a very special little girl....

Jennifer has most recently announced her involvement with a 6-year-old cancer survivor at the hospital named Ellie, who is also Jennifer's co-star in the new PSA for the hospital's annual Thanksgiving campaign over the holiday season.

"When I first met (Jennifer) I liked her, and she was very very nice," Ellie told Access Hollywood. "She said I looked so pretty."

When Ellie was first admitted to St. Jude's, she was diagnosed with a softball-sized tumor on her brain. Since surviving the battle and being chosen to shoot the PSA with Jen, Ellie has gotten the opportunity to stay at one of LA's swankiest hotel's during the project where she and her mother have been treated like stars.

"We are so thankful (for Jen's support) and she was so sweet to Ellie," said Ellie's mother. "She's a great person."

Do you personally know any brave cancer survivors yourself? Tell us their story after the jump!