Christina Applegate

When Will Perez 08 MD 13 found himself sitting in a celebrity-packed Hollywood Palladium on July 19, his Facebook status summed up his reaction: This is surreal. Hollywood is far from his medical classes at Brown, and a world away from the orphanage in Haiti where he lived for a year developing public health programs (see Brown Medicine, Fall 2009).

Watch Honoring Good Guys at VH1’s Do Something Awards 2010 Video Online: Some of Hollywood’s most giving stars were honored at VH1’s Do Something Awards, hosted by Jane Lynch. Hollywood 411 caught up with Kathy Griffin, Christina Applegate, Kellan Lutz, Alyssa Milano and others at the show’s red carpet.

On July 19, "Glee's" Jane Lynch hosted The 2010 Do Something Awards on VH1, honoring celebrities who are giving back as well as activists under the age of 25 who are making a difference in their own communities and around the world. The star-studded evening featured performances by Natasha Bedingfield and Lifehouse, as well as appearances by celebrity presenters like Megan Fox, Matt Bomer, Paula Abdul, and Demi Lovato.

We just love celebs...and Twitter! After spending the night with us at the Do Something Awards, many celebs immediately logged onto their Twitter accounts and tweeted about the show. We’re having a hard time picking our favorite celebrity tweets. Here are the ones that stuck out. View more tweets here