Project SAFE is a multidisciplinary effort to test whether brief motivational interviewing in an emergency department setting may encourage change in sex behaviors and thus prevent gonorrhea, chlamydia, and HIV among male and female patients aged 18-44 years who use heroin and/or crack/cocaine and are not in treatment. The brief motivation interview is designed to facilitate a conversation to illicit a self-determined commitment to changes in behavior by intravenous drug users to reduce the individual's risk for contracting HIV and other sexually transmitted diseases.